| Date | Home | Away | Result |
|---|---|---|---|
| 13/09/22 19:45 | Swansea City | Sheffield United | 0-1 |
| 13/09/22 19:45 | Middlesbrough FC | Cardiff City | 2-3 |
| 13/09/22 19:45 | Blackburn Rovers | Watford FC | 2-0 |
| 13/09/22 19:45 | Hull City A.F.C. | Stoke City | 0-3 |
| 13/09/22 19:45 | Huddersfield Town | Wigan Athletic | 1-2 |
| 13/09/22 20:00 | Preston North End | Burnley FC | 1-1 |
| 14/09/22 19:45 | Rotherham United | FC Blackpool | 3-0 |
| 14/09/22 19:45 | Millwall FC | Queens Park Rangers | 0-2 |
| 14/09/22 19:45 | Norwich City | Bristol City | 3-2 |
| 14/09/22 19:45 | Luton Town | Coventry City | 2-2 |
| 14/09/22 20:00 | Reading FC | AFC Sunderland | 0-3 |
| 14/09/22 20:00 | West Bromwich Albion | Birmingham City | 2-3 |