Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 01/10/21 17:30 | 01/10/21 17:30 | Werder Bremen | 1. FC Heidenheim 1846 | 3-0 | 2 - 4 points |
| 01/10/21 17:30 | 01/10/21 17:30 | Erzgebirge Aue | Hamburger SV | 1-1 | 2 - 4 points |
| 02/10/21 12:30 | 02/10/21 12:30 | Holstein Kiel | FC Hansa Rostock | 0-2 | 2 - 4 points |
| 02/10/21 12:30 | 02/10/21 12:30 | Fortuna Düsseldorf | SC Paderborn 07 | 2-3 | 2 - 4 points |
| 02/10/21 12:30 | 02/10/21 12:30 | Jahn Regensburg | Karlsruher SC | 2-2 | 2 - 4 points |
| 02/10/21 19:30 | 02/10/21 19:30 | 1. FC Nürnberg | Hannover 96 | 0-0 | 2 - 4 points |
| 03/10/21 12:30 | 03/10/21 12:30 | SV Sandhausen | SV Darmstadt 98 | 1-6 | 2 - 4 points |
| 03/10/21 12:30 | 03/10/21 12:30 | FC Schalke 04 | FC Ingolstadt | 3-0 | 2 - 4 points |
| 03/10/21 12:30 | 03/10/21 12:30 | FC St. Pauli | Dynamo Dresden | 3-0 | 2 - 4 points |