Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/03/22 20:00 | 08/03/22 20:00 | FC Bayern Munich | FC Red Bull Salzburg | 7-1 | 2 - 4 points |
| 08/03/22 20:00 | 08/03/22 20:00 | Liverpool FC | Inter Milan | 0-1 | 2 - 4 points |
| 09/03/22 20:00 | 09/03/22 20:00 | Real Madrid | Paris St. Germain | 3-1 | 2 - 4 points |
| 09/03/22 20:00 | 09/03/22 20:00 | Manchester City | Sporting Lisbon | 0-0 | 2 - 4 points |
| 15/03/22 20:00 | 15/03/22 20:00 | Manchester United | Atletico Madrid | 0-1 | 2 - 4 points |
| 15/03/22 20:00 | 15/03/22 20:00 | Ajax Amsterdam | Benfica Lisbon | 0-1 | 2 - 4 points |
| 16/03/22 20:00 | 16/03/22 20:00 | Juventus Turin | FC Villarreal | 0-3 | 2 - 4 points |
| 16/03/22 20:00 | 16/03/22 20:00 | OSC Lille | Chelsea FC | 1-2 | 2 - 4 points |