Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 23/11/21 17:45 | 23/11/21 17:45 | Dynamo Kiew | FC Bayern Munich | Group E | 1-2 | 2 - 4 points |
| 23/11/21 17:50 | 23/11/21 17:50 | FC Villarreal | Manchester United | Group F | 0-2 | 2 - 4 points |
| 23/11/21 20:00 | 23/11/21 20:00 | Malmö FF | Zenit St. Petersburg | Group H | 1-1 | 2 - 4 points |
| 23/11/21 20:00 | 23/11/21 20:00 | Chelsea FC | Juventus Turin | Group H | 4-0 | 2 - 4 points |
| 23/11/21 20:00 | 23/11/21 20:00 | Young Boys Bern | Atalanta Bergamo | Group F | 3-3 | 2 - 4 points |
| 23/11/21 20:00 | 23/11/21 20:00 | FC Sevilla | VfL Wolfsburg | Group G | 2-0 | 2 - 4 points |
| 23/11/21 20:00 | 23/11/21 20:00 | OSC Lille | FC Red Bull Salzburg | Group G | 1-0 | 2 - 4 points |
| 23/11/21 20:00 | 23/11/21 20:00 | FC Barcelona | Benfica Lisbon | Group E | 0-0 | 2 - 4 points |
| 24/11/21 17:45 | 24/11/21 17:45 | Inter Milan | Schachtjor Donezk | Group D | 2-0 | 2 - 4 points |
| 24/11/21 17:45 | 24/11/21 17:45 | Besiktas Istanbul | Ajax Amsterdam | Group C | 1-2 | 2 - 4 points |
| 24/11/21 20:00 | 24/11/21 20:00 | Sheriff Tiraspol | Real Madrid | Group D | 0-3 | 2 - 4 points |
| 24/11/21 20:00 | 24/11/21 20:00 | Atletico Madrid | AC Milan | Group B | 0-1 | 2 - 4 points |
| 24/11/21 20:00 | 24/11/21 20:00 | Liverpool FC | FC Porto | Group B | 2-0 | 2 - 4 points |
| 24/11/21 20:00 | 24/11/21 20:00 | Manchester City | Paris St. Germain | Group A | 2-1 | 2 - 4 points |
| 24/11/21 20:00 | 24/11/21 20:00 | Club Brugge | RB Leipzig | Group A | 0-5 | 2 - 4 points |
| 24/11/21 20:00 | 24/11/21 20:00 | Sporting Lisbon | Borussia Dortmund | Group C | 3-1 | 2 - 4 points |