Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 28/09/21 17:45 | 28/09/21 17:45 | Schachtjor Donezk | Inter Milan | Group D | 0-0 | 2 - 4 points |
| 28/09/21 17:45 | 28/09/21 17:45 | Ajax Amsterdam | Besiktas Istanbul | Group C | 2-0 | 2 - 4 points |
| 28/09/21 20:00 | 28/09/21 20:00 | Real Madrid | Sheriff Tiraspol | Group D | 1-2 | 2 - 4 points |
| 28/09/21 20:00 | 28/09/21 20:00 | FC Porto | Liverpool FC | Group B | 1-5 | 2 - 4 points |
| 28/09/21 20:00 | 28/09/21 20:00 | AC Milan | Atletico Madrid | Group B | 1-2 | 2 - 4 points |
| 28/09/21 20:00 | 28/09/21 20:00 | RB Leipzig | Club Brugge | Group A | 1-2 | 2 - 4 points |
| 28/09/21 20:00 | 28/09/21 20:00 | Paris St. Germain | Manchester City | Group A | 2-0 | 2 - 4 points |
| 28/09/21 20:00 | 28/09/21 20:00 | Borussia Dortmund | Sporting Lisbon | Group C | 1-0 | 2 - 4 points |
| 29/09/21 17:45 | 29/09/21 17:45 | Zenit St. Petersburg | Malmö FF | Group H | 4-0 | 2 - 4 points |
| 29/09/21 17:45 | 29/09/21 17:45 | Atalanta Bergamo | Young Boys Bern | Group F | 1-0 | 2 - 4 points |
| 29/09/21 20:00 | 29/09/21 20:00 | Juventus Turin | Chelsea FC | Group H | 1-0 | 2 - 4 points |
| 29/09/21 20:00 | 29/09/21 20:00 | VfL Wolfsburg | FC Sevilla | Group G | 1-1 | 2 - 4 points |
| 29/09/21 20:00 | 29/09/21 20:00 | FC Red Bull Salzburg | OSC Lille | Group G | 2-1 | 2 - 4 points |
| 29/09/21 20:00 | 29/09/21 20:00 | Benfica Lisbon | FC Barcelona | Group E | 3-0 | 2 - 4 points |
| 29/09/21 20:00 | 29/09/21 20:00 | FC Bayern Munich | Dynamo Kiew | Group E | 5-0 | 2 - 4 points |
| 29/09/21 20:00 | 29/09/21 20:00 | Manchester United | FC Villarreal | Group F | 2-1 | 2 - 4 points |