Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 16/10/21 23:00 | 16/10/21 23:00 | AF Chapecoense | Fortaleza | 1-2 | 2 - 4 points |
| 17/10/21 01:00 | 17/10/21 01:00 | America FC | Bahia BA | 0-0 | 2 - 4 points |
| 17/10/21 20:00 | 17/10/21 20:00 | Palmeiras | Internacional | 1-0 | 2 - 4 points |
| 17/10/21 20:00 | 17/10/21 20:00 | Athletico Paranaense | Fluminense | 0-1 | 2 - 4 points |
| 17/10/21 22:15 | 17/10/21 22:15 | Gremio Porto Alegre | EC Juventude | 3-2 | 2 - 4 points |
| 17/10/21 22:15 | 17/10/21 22:15 | Atletico Goianiense | Club Atletico Mineiro | 2-1 | 2 - 4 points |
| 17/10/21 22:15 | 17/10/21 22:15 | Ceará | Red Bull Bragantino | 2-2 | 2 - 4 points |
| 18/10/21 00:30 | 18/10/21 00:30 | Flamengo | Cuiaba EC | 0-0 | 2 - 4 points |
| 18/10/21 00:30 | 18/10/21 00:30 | Sport Recife | FC Santos | 0-0 | 2 - 4 points |
| 19/10/21 00:00 | 19/10/21 00:00 | FC Sao Paulo | Corinthians | 1-0 | 2 - 4 points |