Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/10/21 23:00 | 12/10/21 23:00 | Red Bull Bragantino | Atletico Goianiense | 1-0 | 2 - 4 points |
| 13/10/21 01:30 | 13/10/21 01:30 | Bahia BA | Palmeiras | 0-0 | 2 - 4 points |
| 13/10/21 23:00 | 13/10/21 23:00 | Flamengo | EC Juventude | 3-1 | 2 - 4 points |
| 13/10/21 23:00 | 13/10/21 23:00 | AF Chapecoense | Athletico Paranaense | 1-1 | 2 - 4 points |
| 13/10/21 23:00 | 13/10/21 23:00 | Club Atletico Mineiro | FC Santos | 3-1 | 2 - 4 points |
| 14/10/21 00:30 | 14/10/21 00:30 | Fortaleza | Gremio Porto Alegre | 1-0 | 2 - 4 points |
| 14/10/21 01:00 | 14/10/21 01:00 | Corinthians | Fluminense | 1-0 | 2 - 4 points |
| 14/10/21 01:30 | 14/10/21 01:30 | Internacional | America FC | 3-1 | 2 - 4 points |
| 14/10/21 23:00 | 14/10/21 23:00 | Cuiaba EC | Sport Recife | 1-0 | 2 - 4 points |
| 14/10/21 23:00 | 14/10/21 23:00 | FC Sao Paulo | Ceará | 1-1 | 2 - 4 points |